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- Title
RHABDOMYOSARCOMA IN CHILDREN -- CURRENT PATHOLOGIC AND MOLECULAR CLASSIFICATION.
- Authors
DZIUBA, IRENEUSZ; KURZAWA, PAWEŁ; DOPI ERAŁA, MICHAŁ; LARQUE, ANA B.; EWICZ-LEWANDOWSKA, DANUTA JANUSZKI
- Abstract
The last 25 years have brought significant progress in the treatment of sarcomas in children, especially rhabdomyosarcoma (RMS). Nevertheless, treatment failure in some patients results from considerable biological heterogeneity noted in these tumours. RMS, the most common malignant soft tissue neoplasm in children, includes two main subtypes: embryonal (ERMS) and alveolar (ARMS). Due to greater aggressiveness and worse prognosis of ARMS in comparison to ERMS, discrimination between different rhabdomyosarcoma subtypes is of crucial clinical importance. This paper presents the current histological classification of RMS, up-to-date immunohistochemical and biological research regarding RMS, and its associated clinical and prognostic significance.
- Publication
Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists, 2018, Vol 69, Issue 1, p20
- ISSN
1233-9687
- Publication type
Article
- DOI
10.5114/pjp.2018.75333