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- Title
Oral administration of Clostridium butyricum CGMCC0313-1 inhibits β-lactoglobulin-induced intestinal anaphylaxis in a mouse model of food allergy.
- Authors
Juan Zhang; Hui Su; Qiuhong Li; Haixia Wu; Mengyun Liu; Jianqiong Huang; Minghua Zeng; Yuejie Zheng; Xin Sun
- Abstract
Background: Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. There has been a growing interest in the use of beneficial bacteria for allergic diseases recently. This study aimed at exploring whether Clostridium butyricum CGMCC0313-1 (C. butyricum) can reduce â-lactoglobulin(BLG)-induced intestinal anaphylaxis in a murine model of food allergy. Methods: The preventive and therapeutic effects of oral C. butyricum on anaphylactic symptoms induced via BLG in food allergy mice were investigated. Intestinal anaphylaxis, T helper (Th)-specific cytokines and transcription factors, secretory IgA (sIgA), CD4+ CD25+ Foxp3Treg cell and histopathological alterations were examined. Results: Clostridium butyricum significantly ameliorated intestinal anaphylaxis symptoms in the food allergy mice. sIgA and CD4+ CD25+ Foxp3Treg cell were increased by oral C. butyricum. It also reversed the imbalance of Th1/Th2 andTh17/Treg. Conclusions: Clostridium butyricum reduces BLG-induced intestinal anaphylaxis in mice and might be an additional or supplementary therapy for food allergy.
- Subjects
ALLERGY treatment; FOOD allergy; ORAL drug administration; CLOSTRIDIUM butyricum; LACTOGLOBULINS; ANAPHYLAXIS; LABORATORY mice
- Publication
Gut Pathogens, 2017, Vol 9, p1
- ISSN
1757-4749
- Publication type
Article
- DOI
10.1186/s13099-017-0160-6