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- Title
Time Course of Postnatal Distribution of Doublecortin Immunoreactive Developing/Maturing Neurons in the Somatosensory Cortex and Hippocampal CA1 Region of C57BL/6 Mice.
- Authors
Dae Young Yoo; Ki-Yeon Yoo; Ji Won Choi; Woosuk Kim; Choong Hyun Lee; Jung Hoon Choi; Jeong Ho Park; Moo-Ho Won; In Koo Hwang
- Abstract
In this study, we observed neuroblast differentiation in the somatosensory cortex (SSC) and hippocampal CA1 region (CA1), which is vulnerable to oxidative stress, of the mouse at various early postnatal days (P) 1, 7, 14, and 21 using doublecortin (DCX, a marker for neuroblasts). Cresyl violet and NeuN (Neuronal Nuclei) staining showed development of layers as well as neurons in the SSC and CA1. At P1, DCX-positive neuroblasts expressed strong DCX immunoreactivity in both the SSC and CA1. Thereafter, DCX immunoreactivity was decreased with time. At P7, many DCX-immunoreactive neuroblasts were well detected in the SSC and CA1. At P14, some DCX-positive neuroblasts were found in the SSC and CA1: The immunoreactivity was weak. At P21, DCX immunoreactivity was hardly found in cells in the SSC and CA1. These results suggest that DCX-positive neuroblasts were significantly decreased in the mouse SSC and CA1 from P14.
- Subjects
DEVELOPMENTAL neurobiology; CEREBRAL cortex; HIPPOCAMPUS (Brain); OXIDATIVE stress; NEURONS; CELLS
- Publication
Cellular & Molecular Neurobiology, 2011, Vol 31, Issue 5, p729
- ISSN
0272-4340
- Publication type
Article
- DOI
10.1007/s10571-011-9670-9