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- Title
KIF3A, a Cilia Structural Gene on Chromosome 5q31, and Its Polymorphisms Show an Association with Aspirin Hypersensitivity in Asthma.
- Authors
Kim, Jeong-Hyun; Cha, Ji-Yeon; Cheong, Hyun; Park, Jong; Jang, An; Uh, Soo-Taek; Kim, Mi-Kyeong; Choi, Inseon; Cho, Sang; Park, Byung-Lae; Bae, Joon; Park, Choon-Sik; Shin, Hyoung
- Abstract
Introduction: The kinesin family number 3A ( KIF3A) gene on the human chromosomal 5q31-33 region, which is known as a susceptibility locus for immune diseases including asthma, plays a crucial role in generation of cilia. Results: A treatment with aspirin in the human bronchial epithelial cells increased the mRNA expression level of KIF3A compared to that of the untreated control ( P ≤ 0.01), and nasal polyp epithelia from aspirin-intolerant asthma (AIA) patients also showed a higher expression of KIF3A protein than aspirin-tolerant asthma controls. Further logistic analyses revealed that most polymorphisms of KIF3A were significantly associated with AIA ( P = 0.0004-0.02; P = 0.004-0.04) and the decline of forced expiratory volume at 1 s (FEV)% by aspirin provocation ( P = 0.004-0.04; P = 0.03). Discussion: Our findings suggest that the KIF3A gene and/or its polymorphisms might have a susceptibility effect on AIA, providing a new step toward controlling aspirin intolerance in asthmatics.
- Subjects
ASPIRIN; DRUG allergy; GENETIC polymorphisms; HUMAN chromosomes; ASTHMA; KINESIN; MESSENGER RNA; IMMUNOLOGIC diseases; GENETICS
- Publication
Journal of Clinical Immunology, 2011, Vol 31, Issue 1, p112
- ISSN
0271-9142
- Publication type
Article
- DOI
10.1007/s10875-010-9462-x