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- Title
Primordial non-responsiveness: a neglected obstacle to cardioprotection.
- Authors
Heusch, Gerd; Bøtker, Hans Erik; Ferdinandy, Péter; Schulz, Rainer
- Abstract
Basic Res Cardiol 2022; 117: 58. http://doi.org/10.1007/s00395- 022- 00965-0 Google Scholar Crossref Search ADS PubMed WorldCat 12 Lieder HR, Skyschally A, Sturek M, Heusch G, Kleinbongard P. Remote ischemic conditioning in Ossabaw minipigs induces the release of humoral cardioprotective triggers, but the myocardium does not respond with reduced infarct size. There is still a need for cardioprotection beyond that by rapid reperfusion, because 1-year mortality after reperfused acute myocardial infarction is still above 10% and the incidence of post-infarct heart failure still around 20%-30%. DIAGRAM: Graphical Abstract Schematic diagram listing the established confounders of cardioprotection and characterizing in more detail the features of the novel confounder "primordial non-responsiveness to cardioprotection", as evidenced by lack of protection (reduced arrhythmias, contractile dysfunction, infarct size, and coronary microvascular obstruction) from ischaemic conditioning interventions in rat and pig strains.
- Subjects
MYOCARDIAL infarction; REPERFUSION injury; ISCHEMIC preconditioning; ISCHEMIC conditioning
- Publication
European Heart Journal, 2023, Vol 44, Issue 19, p1687
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/ehad160