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- Title
Primitive origins of prostate cancer: In vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells
- Authors
Goldstein, Andrew S.; Stoyanova, Tanya; Witte, Owen N.
- Abstract
Abstract: Tissue stem cells have been linked to cancers of epithelial origin including the prostate. There are three relevant issues concerning stem cells and cancer that rely solely on functional studies: 1. Are there tissue-regenerating stem cells in the adult organ? 2. Can tissue-regenerating cells serve as targets for transformation? 3. Do primary tumors contain tumor-propagating (cancer stem) cells? We will review the recent literature with respect to these critical issues to provide a direct link between primitive cells and prostate cancer.
- Subjects
PROSTATE cancer; CANCER relapse; ANDROGENS; HORMONE receptors; PHOSPHOINOSITIDES; STEM cells; KERATIN; PROSTATE-specific antigen
- Publication
Molecular Oncology, 2010, Vol 4, Issue 5, p385
- ISSN
1574-7891
- Publication type
Article
- DOI
10.1016/j.molonc.2010.06.009