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- Title
Characterizations of oral microbiota in elderly nursing home residents with diabetes.
- Authors
Taiji Ogawa; Mariko Honda-Ogawa; Kazunori Ikebe; Yumiko Notomi; Yoshiko Iwamoto; Itsuki Shirobayashi; Seiko Hata; Masahito Kibi; Shizuko Masayasu; Satoshi Sasaki; Shigetada Kawabata; Yoshinobu Maeda; Ogawa, Taiji; Honda-Ogawa, Mariko; Ikebe, Kazunori; Notomi, Yumiko; Iwamoto, Yoshiko; Shirobayashi, Itsuki; Hata, Seiko; Kibi, Masahito
- Abstract
Over 700 bacterial species have been detected in the oral cavity. Several studies have suggested that periodontitis is associated with systemic disorders such as diabetes mellitus, indicating a key role for oral microbiota in human health. However, the relationship between oral microbiota and diabetes has not been well clarified. Therefore, we conducted microbiome analysis of saliva samples obtained from 15 elderly residents (3 with type 2 diabetes mellitus [DM] and 12 without diabetes [non-DM]) at three different nursing homes, as well as 9 young healthy controls (HC). Genomic DNA was extracted from each sample, and then the V4 region of the 16S rRNA gene was amplified and sequenced. Alpha diversity, in terms of operational taxonomic unit richness, was significantly higher in samples from the non-DM group than in those from the HC group. Weighted UniFrac distance analysis showed that salivary microbial communities in the DM group were separately clustered. Furthermore, in the DM group, Actinomyces and Selenomonas showed significantly higher abundance, whereas Alloprevotella showed significantly lower abundance, relative to the non-DM group. Although our findings were limited by the small sample size, oral bacterial diversity in the DM group was clearly different from that in the non-DM group.
- Subjects
PERIODONTITIS; ORAL microbiology; PEOPLE with diabetes; NURSING care facilities; DISEASES in older people; SALIVA microbiology; DIET; HEALTH services accessibility; TYPE 2 diabetes; RNA; TOOTH care &; hygiene; LIFESTYLES; CASE-control method; SEQUENCE analysis
- Publication
Journal of Oral Science, 2017, Vol 59, Issue 4, p549
- ISSN
1343-4934
- Publication type
journal article
- DOI
10.2334/josnusd.16-0722