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- Title
Crystal Structure Determination for Eugenyl Acetate.
- Authors
Gilberto Chierice; Kenneth Alexander
- Abstract
Abstract Essential oils are good candidates for the substitution of conventional medicinal treatments. Many articles and patents for their use have been published in recent years. The most attractive aspects of using essential oils as medicaments are their natural source and rapid permeability. Besides permeability, the solubility behavior of a drug is a key determinant of its oral bioavailability. Based on these characteristics, the aim of this study was to synthesize an essential oil derivative compound, using the raw oil extracted from Syzygium aromaticum L., without previous purification. The Eugenol molecular modification may diminish the problems of water solubility and bioavailability. The Eugenyl acetate molecule was characterized and its molecular modification investigated, including its structural properties and stereochemistry. This study was performed applying techniques, such as carbon-13 nuclear magnetic resonance spectroscopy (C-13 NMR), X-ray crystallographic analysis (XRD), powder X-ray diffraction (PXRD) and microscopic recording. Graphical Abstract Eugenol and its structure have been known for many years, where as Eugenyl acetate’s structure has never been elucidated nor confirmed until now.
- Subjects
MOLECULAR structure; CRYSTALS; ACETATES; ESSENTIAL oils; PERMEABILITY; MEDICINE; PATENTS; MEDICAL publishing
- Publication
Journal of Chemical Crystallography, 2009, Vol 39, Issue 9, p655
- ISSN
1074-1542
- Publication type
Article