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- Title
Peripheral Administration of a Humanized Anti-PrP Antibody Blocks Alzheimer's Disease Aβ Synaptotoxicity.
- Authors
Klyubin, Igor; Nicoll, Andrew J.; Khalili-Shirazi, Azadeh; Farmer, Michael; Canning, Stephanie; Mably, Alexandra; Linehan, Jacqueline; Brown, Alexander; Wakeling, Madeleine; Brandner, Sebastian; Walsh, Dominic M.; Rowan, Michael J.; Collinge, John
- Abstract
Alzheimer's disease (AD) is associated with pathological assembly states of amyloid-β protein (Aβ). Aβ-related synaptotoxicity can be blocked by anti-prion protein (PrP) antibodies, potentially allowing therapeutic targeting of this aspect of AD neuropathogenesis. Here, we show that intravascular administration of a high-affinity humanized anti-PrP antibody to rats can prevent the plasticity-disrupting effects induced by exposure to solubleADbrain extract. These results provide an in vivo proof of principle for such a therapeutic strategy.
- Subjects
ALZHEIMER'S disease treatment; AMYLOID beta-protein; NEUROPLASTICITY; DRUG administration; IMMUNOTHERAPY; NEUROTOXICOLOGY; PRIONS
- Publication
Journal of Neuroscience, 2014, Vol 34, Issue 18, p6140
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.3526-13.2014