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- Title
Successful treatment of acute myelomonocytic leukaemia with NUP98–HOXD11 fusion transcripts and monitoring of minimal residual disease.
- Authors
Terui, Kiminori; Kitazawa, Junichi; Takahashi, Yoshihiro; Tohno, Chikako; Hayashi, Yasuhide; Taketani, Takeshi; Taki, Tomohiko; Ito, Etsuro
- Abstract
Summary. Patients with haematological malignancies involving the NUP98 gene have been reported to have an aggressive clinical course and a poor outcome. We report successful treatment of a 15-year-old Japanese boy with acute myelomonocytic leukaemia having t(2;11)(q31;p15) and a novel fusion transcript, NUP98–HOXD11 . He achieved complete remission by combined chemotherapy, and underwent unrelated cord blood transplantation 4 months after diagnosis. He is in complete remission 24 months after diagnosis. Monitoring of minimal residual disease (MRD) showed the absence of fusion transcript 12 months after transplantation. This is the first report of monitoring MRD in a patient with haematological malignancy involving NUP98 fusion transcripts.
- Subjects
LEUKEMIA treatment; GENE fusion; DRUG therapy; SPONTANEOUS cancer regression
- Publication
British Journal of Haematology, 2003, Vol 120, Issue 2, p274
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2003.04052.x