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- Title
Three cases of typical aplastic anaemia associated with a Philadelphia chromosome.
- Authors
Suzan, F.; Terré, C.; Garcia, I.; Bastie, J. N.; Baumelou, E.; Gluckman, E.; Castaigne, S.
- Abstract
We report three cases of typical aplastic anaemia (AA) associated with a Philadelphia chromosome. This translocation was detected at the time of diagnosis of AA (one patient) and when overt leukaemia was diagnosed (two patients: one chronic myeloid leukaemia and one acute lymphoblastic leukaemia) after AA therapy and recovery of blood counts. We discuss the literature arguments about considering some cases of AA as preleukaemic disorders and suggest that our cases illustrate the association of AA with a clonal malignant disorder. We conclude that cytogenetic analysis is necessary at diagnosis of AA or after recovery of blood counts.
- Subjects
APLASTIC anemia; LEUKEMIA
- Publication
British Journal of Haematology, 2001, Vol 112, Issue 2, p385
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2001.02594.x