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- Title
AN AGGRESSIVE DESMOID TUMOR IN A PATIENT WITH FAMILIAL ADENOMATOUS POLYPOSIS: IMMUNOHISTOCHEMICAL FINDINGS.
- Authors
Arai, Nobuyasu; Mitomi, Hiroyuki; Uesugi, Hidenaga; Aihara, Sigeaki; Ohtani, Yoshimasa; Okayasu, Isao
- Abstract
A case of an aggressive desmoid tumor in a patient with familial adenomatous polyposis is described. The lesion rapidly enlarged with compression of adjacent structures including the ureter and small bowel, and the patient died because of small bowel perforation and hydronephrosis 3 years after detection of small desmoid tumors at the time of a prophylactic coloproctectomy for a colon carcinoma. Immunohistochemically, proliferating cell nuclear antigen (PCNA), p21WAF1/CIP1 cathepsin D indices, but not the bcl-2 index, which were defined as the numbers of immunoreactive tumor cells per 1000 tumor cells, increased in line with tumor progression. The tumor did not show staining for collagen IV, but was characterized by intense staining for basic fibroblast growth factor (bFGF). Accordingly, tumor aggression was related to increases in both cell proliferation and protease activity, as well as an enhanced expression of bFGF. In addition, the desmoid tumor showed deregulation between PCNA and p21WAF1/CIP1 because the normal inverse relation between these two was not apparent.
- Subjects
ADENOMA; IMMUNOHISTOCHEMISTRY; FAMILIAL diseases; CANCER cells; CELL proliferation; CANCER invasiveness
- Publication
American Journal of Gastroenterology (Springer Nature), 1999, Vol 94, Issue 2, p530
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.1999.00814.x