We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Do GLP-1 Receptor Agonists Increase the Risk of Breast Cancer? A Systematic Review and Meta-analysis.
- Authors
Piccoli, Giovana F.; Mesquita, Leonardo A.; Stein, Cinara; Aziz, Marina; Zoldan, Maira; Degobi, Nathália A. H.; Spiazzi, Bernardo F.; Lopes Junior, Gilberto L.; Colpani, Verônica; Gerchman, Fernando
- Abstract
<bold>Context: </bold>Risk of cancer is a major concern in the development of drugs for the treatment of obesity and diabetes. In randomized controlled trials (RCTs) of the Liraglutide Clinical Development Program, subjects treated with a glucagon-like peptide-1 receptor agonist (GLP-1RA) had a higher absolute number of breast cancer events.<bold>Objective: </bold>To assess whether patients treated with GLP-1RAs had a higher risk of breast neoplasms.<bold>Data Sources: </bold>We searched MEDLINE, Embase, Web of Science, and CENTRAL from July 31, 2019 to February 8, 2020.<bold>Study Selection: </bold>Reviewers assessed abstracts and full-text articles for RCTs of GLP-1RAs in adults with excessive weight and/or diabetes and a minimum follow-up of 24 weeks.<bold>Data Extraction: </bold>Researchers extracted study-level data and assessed within-study risk of bias with the RoB 2.0 tool and quality of evidence with Grading of Recommendations Assessment, Development and Evaluation (GRADE).<bold>Data Synthesis: </bold>We included 52 trials, of which 50 reported breast cancer events and 11 reported benign breast neoplasms. Overall methodological quality was high. Among 48 267 subjects treated with GLP-1RAs, 130 developed breast cancer compared with 107 of 40 755 controls (relative risk [RR], 0.98; 95% confidence interval [CI], 0.76-1.26). Subset analyses according to follow-up, participant/investigator blinding, and type of GLP-1RA did not reveal any differences. The risk of benign breast neoplasms also did not differ between groups (RR, 0.99; 95% CI, 0.48-2.01). Trial sequential analysis provided evidence that the sample size was sufficient to avoid missing alternative results.<bold>Conclusions: </bold>Treatment with GLP-1RAs for obesity and diabetes does not increase the risk of breast neoplasms.
- Subjects
INSULIN aspart; GLUCAGON-like peptide-1 agonists; BREAST cancer; MEDICAL sciences; GLUCAGON-like peptide 1; ANTIOBESITY agents; OBESITY; RELATIVE medical risk; META-analysis; SYSTEMATIC reviews; HYPOGLYCEMIC agents; TYPE 2 diabetes; BREAST tumors
- Publication
Journal of Clinical Endocrinology & Metabolism, 2021, Vol 106, Issue 3, p912
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgaa891