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- Title
Implantation of an Atelocollagen Sheet for the Treatment of Vocal Fold Scarring and Sulcus Vocalis.
- Authors
Kishimoto, Yo; Hirano, Shigeru; Kojima, Tsuyoshi; Kanemaru, Shin-ichi; Ito, Juichi
- Abstract
Objectives: The management of vocal fold scarring and sulcus vocaHs is challenging. These disorders are thought to be fibroplastic anomalies in the cover portion of the vocal fold that cause deterioration of the vibratory properties of the vocal fold mucosa. Histologic studies have revealed disorganization of extracellular matrix that needs to be addressed in the treatment of scarred vocal folds. Replacement of scar tissues with an appropriate implant may lead to regeneration of the vocal fold mucosa and its tissue properties. This retrospective case study examined the feasibility of using an atelocollagen sheet as a regenerative implant. Methods: Six patients with a post-cordectomy scar or sulcus vocalis underwent implantation of an atelocollagen sheet into the lamina propria of the vocal folds. The procedure consisted of elevation of a microflap, dissection and removal of scar tissue, implantation of the material, and wound closure. Vocal function was evaluated before and after surgery by stroboscopic examination and by aerodynamic and acoustic analyses. Results: The postoperative changes of aerodynamic and acoustic parameters varied among patients; however, gradual improvement was seen in most cases over a year. Stroboscopic findings also revealed gradual improvement of vibratory properties in most cases. Conclusions: Implantation of an atelocollagen sheet may have restorative effects on vocal fold scarring and sulcus vocalis in terms of tissue properties and function of the mucosa.
- Subjects
VOCAL cords; MUCOUS membranes; EXTRACELLULAR matrix; SCARS; HISTOLOGY
- Publication
Annals of Otology, Rhinology & Laryngology, 2009, Vol 118, Issue 9, p613
- ISSN
0003-4894
- Publication type
Article
- DOI
10.1177/000348940911800902