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- Title
Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study.
- Authors
Freynet, Olivia; Marchal-Sommé, Joëlle; Jean-Louis, Francette; Mailleux, Arnaud; Crestani, Bruno; Soler, Paul; Michel, Laurence
- Abstract
In human lung fibrotic lesions, fibroblasts were shown to be closely associated with immature dendritic cell (DC) accumulation. The aim of the present pilot study was to characterize the role of pulmonary fibroblasts on DC phenotype and function, using co-culture of lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) and from control patients, with a DC cell line MUTZ-3. We observed that co-culture of lung control and IPF fibroblasts with DCs reduced the expression of specific DC markers and down-regulated their T-cell stimulatory activity. This suggests that pulmonary fibroblasts might sustain chronic inflammation in the fibrotic lung by maintaining in situ a pool of immature DCs.
- Subjects
FIBROBLASTS; DENDRITIC cells; IDIOPATHIC pulmonary fibrosis; T cells; CELL differentiation; PATIENTS; CELL culture; CELL communication; CELL physiology; CYTOKINES; LUNGS; PHENOTYPES; PILOT projects; IN vitro studies
- Publication
Respiratory Research, 2016, Vol 17, p1
- ISSN
1465-9921
- Publication type
letter
- DOI
10.1186/s12931-016-0345-4