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- Title
Exploratory Pharmacokinetics of Geniposide in Rat Model of Cerebral Ischemia Orally Administered with or without Baicalin and/or Berberine.
- Authors
Linmei Pan; Wenzhe Wang; Feiyan Shi; Jing Zhou; Meng Zhang; Huaxu Zhu; Mingfei Zeng
- Abstract
Huang-Lian-Jie-Du-Tang (HLJDT), a classical Chinese prescription, has been clinically employed to treat cerebral ischemia for thousands of years. Geniposide is the major active ingredient in HLJDT. The aim is to investigate the comparative evaluations on pharmacokinetics of geniposide in MCAO rats in pure geniposide, geniposide: berberine, and geniposide: berberine: baicalin. Obviously, the proportions of geniposide: berberine, geniposide: baicalin, and geniposide: berberine: baicalin were determined according to HLJDT. In our study, the cerebral ischemia model was reproduced by suture method in rats. The MCAO rats were randomly assigned to four therapy groups and orally administered with different prescription proportions of pure geniposide, geniposide: berberine, geniposide: baicalin, and geniposide: berberine: baicalin, respectively. The concentrations of geniposide in rat serum were determined using HPLC, and main pharmacokinetic parameters were investigated. The results indicated that the pharmacokinetics of geniposide in rat serum was nonlinear and there were significant differences between different groups. Berberine might hardly affect the absorption of geniposide, and baicalin could increase the absorption ability of geniposide. Meanwhile, berberine could decrease the absorption increase of baicalin on geniposide.
- Subjects
CHINA; ALTERNATIVE medicine; ANALYSIS of variance; ANIMAL experimentation; BIOPHYSICS; CEREBRAL ischemia; COMPARATIVE studies; DRUG synergism; HIGH performance liquid chromatography; RESEARCH methodology; MEDICINAL plants; BOTANIC medicine; RATS; RESEARCH funding; STATISTICS; PLANT extracts; DATA analysis; DATA analysis software; DESCRIPTIVE statistics
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2013, Vol 2013, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2013/349531