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- Title
The toxic effect of cypermethrin, amitraz and combinations of cypermethrin-amitraz in rats.
- Authors
Kanbur, Murat; Siliğ, Yavuz; Eraslan, Gökhan; Karabacak, Mürsel; Soyer Sarıca, Zeynep; Şahin, Serap
- Abstract
In this study, the effects of cypermethrin (CYP), amitraz (AMT) and combined cypermethrin-amitraz (CYP-AMT) on some serum biochemical, oxidative stress and drug-metabolising parameters were investigated in male Wistar albino rats. CYP, AMT and combined CYP-AMT were administered at doses of 80 mg kg bw of CYP and 170 mg kg bw of AMT for 1 day (single dose), and at doses of 12 mg kg bw of CYP and 25 mg kg bw of AMT for 40 days by oral gavage. Oxidative stress (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glucose-6-phosphate dehydrogenase (G6PD)), serum biochemical (glucose, triglyceride, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), blood urea nitrogen (BUN), creatinine, asparatate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total protein, albumin) in blood/tissues (liver, kidney, brain, spleen and testis) and hepatic drug-metabolising (cytochrome P450 2E1 (CYP2E1), NADH-cytochrome b reductase (CYPb5), NADPH-cytochrome c reductase/NADPH cytocrome P450 reductase (CYTC), glutathione S-transferase (GST), glutathione (GSH)) parameters were measured in liver samples taken on days 1 and 40. In result, it was determined that CYP, AMT and their combinations led to significant changes in the parameters investigated, and it was ascertained that long-term exposure to insecticides and the administration of insecticide combinations produced greater toxic effects in comparison with the administration of insecticides alone.
- Subjects
CYPERMETHRIN; PYRETHROIDS; LABORATORY rats; MURIDAE; OXIDATIVE stress
- Publication
Environmental Science & Pollution Research, 2016, Vol 23, Issue 6, p5232
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-015-5720-z