We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Structurally Homogeneous Nanosheets from Self-Assembly of a Collagen-Mimetic Peptide.
- Authors
Jiang, Tao; Xu, Chunfu; Zuo, Xiaobing; Conticello, Vincent P.
- Abstract
A collagen-mimetic peptide, NSIII, has been designed with three sequential blocks having positive, neutral, and negative charges, respectively. The non-canonical imino acid, (2 S,4 S)-4-aminoproline (amp), was used to specify the positive charges at the Xaa positions of (Xaa-Yaa-Gly) triads in the N-terminal domain of NSIII. Peptide NSIII underwent self-assembly from aqueous solution to form a highly homogeneous population of nanosheets. Two-dimensional crystalline sheets formed in which the length of the peptide defined the height of the sheets. These results contrasted with prior results on a similar multi-domain collagen-mimetic polypeptides in which the sheets had highly polydisperse distribution of sizes in the ( x/ y)- and ( z)-dimensions. The structural differences between the two nanosheet assemblies were interpreted in terms of the relative stereoelectronic effects of the different aminoproline derivatives on the local triple helical conformation of the peptides.
- Subjects
MOLECULAR self-assembly; COLLAGEN; IMINO acids; N-terminal residues; NANOSTRUCTURED materials
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 32, p8507
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201403780