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The bacterial gene lfpA influences the potent induction of calcitonin receptor and osteoclast-related genes in Burkholderia pseudomallei-induced TRAP-positive multinucleated giant cells.
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- Cellular Microbiology, 2007, v. 9, n. 2, p. 514, doi. 10.1111/j.1462-5822.2006.00807.x
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- Article
Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) Drives Activation of Bone Remodelling and Skeletal Metastasis.
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- Current Osteoporosis Reports, 2019, v. 17, n. 6, p. 538, doi. 10.1007/s11914-019-00545-7
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- Article
Monocyte Chemotactic Protein-1 (MCP1) Accumulation in Human Osteoclast Precursor Cultures.
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- Life (2075-1729), 2022, v. 12, n. 6, p. 789, doi. 10.3390/life12060789
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- Article
Monocyte chemoattractant protein-1 is a mediator of the anabolic action of parathyroid hormone on bone.
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- Journal of Bone & Mineral Research, 2013, v. 28, n. 9, p. 1975, doi. 10.1002/jbmr.1933
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- Article
Expression Profile of RhoGTPases and RhoGEFs During RANKL-Stimulated Osteoclastogenesis: Identification of Essential Genes in Osteoclasts.
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- Journal of Bone & Mineral Research, 2006, v. 21, n. 9, p. 1387, doi. 10.1359/jbmr.060613
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- Article
Association of Functionally Different RUNX2 P2 Promoter Alleles With BMD.
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- Journal of Bone & Mineral Research, 2006, v. 21, n. 2, p. 265, doi. 10.1359/JBMR.051013
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- Article
Regulation of Human Osteoclast Differentiation by Thioredoxin Binding Protein-2 and Redox-Sensitive Signaling.
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- Journal of Bone & Mineral Research, 2004, v. 19, n. 12, p. 2057, doi. 10.1359/jbmr.040913
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- Article
Alleles of RUNX2/CBFA1 Gene Are Associated With Differences in Bone Mineral Density and Risk of Fracture.
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- Journal of Bone & Mineral Research, 2002, v. 17, n. 8, p. 1527, doi. 10.1359/jbmr.2002.17.8.1527
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- Article
Vitamin D receptor alleles, bone mineral density and turnover in premenopausal Japanese women.
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- Journal of Bone & Mineral Research, 1996, v. 11, n. 7, p. 1003, doi. 10.1002/jbmr.5650110718
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- Article
The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women.
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- Journal of Bone & Mineral Research, 1995, v. 10, n. 6, p. 991, doi. 10.1002/jbmr.5650100622
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- Article
Transcriptional activation of the human osteocalcin gene by basic fibroblast growth factor.
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- Journal of Bone & Mineral Research, 1994, v. 9, n. 2, p. 143, doi. 10.1002/jbmr.5650090203
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- Article
Role of the negative glucocorticoid regulatory element in glucocorticoid repression of the human osteocalcin promoter.
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- Journal of Bone & Mineral Research, 1993, v. 8, n. 8, p. 969, doi. 10.1002/jbmr.5650080810
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- Article
Prediction of bone density from vitamin D receptor alleles.
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- Nature, 1994, v. 367, n. 6460, p. 284, doi. 10.1038/367284a0
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- Article
Polyalanine Repeat Polymorphism in <i>RUNX2</i> Is Associated with Site-Specific Fracture in Post-Menopausal Females.
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- PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0072740
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- Article
Quorum Sensing Negatively Regulates Multinucleate Cell Formation during Intracellular Growth of <i>Burkholderia pseudomallei</i> in Macrophage-Like Cells
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- PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0063394
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- Article
RUNX2 is an essential transcription factor required for skeletal development and cartilage formation. Haploinsufficiency of RUNX2 leads to cleidocranial displaysia (CCD) a skeletal disorder characterised by gross dysgenesis of bones particularly those derived from intramembranous bone formation. A notable feature of the RUNX2 protein is the polyglutamine and polyalanine (23Q/17A) domain coded by a repeat sequence. Since none of the known mutations causing CCD characterised to date map in the glutamine repeat region, we hypothesised that Q-repeat mutations may be related to a more subtle bone phenotype. We screened subjects derived from four normal populations for Q- repeat variants. A total of 22 subjects were identified who were heterozygous for a wild type allele and a Q-repeat variant allele: (15Q, 16Q, 18Q and 30Q). Although not every subject had data for all measures, Q-repeat variants had a significant deficit in BMD with an average decrease of 0.7SD measured over 12 BMD-related parameters (p = 0.005). Femoral neck BMD was measured in all subjects (--0.6SD, p = 0.0007). The transactivation function of RUNX2 was determined for 16Q and 30Q alleles using a reporter gene assay. 16Q and 30Q alleles displayed significantly lower transactivation function compared to wild type (23Q). Our analysis has identified novel Q-repeat mutations that occur at a collective frequency of about 0.4%. These mutations significantly alter BMD and display impaired transactivation function, introducing a new class of functionally relevant RUNX2 mutants.
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- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042617
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- Article
Nonhypercalcemic 1,25-(OH)<sub>2</sub>D<sub>3</sub> analogs potently induce the human osteocalcin gene promoter stably transfected into rat osteosarcoma cells (ROSCO-2).
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- Journal of Bone & Mineral Research, 1991, v. 6, n. 8, p. 893, doi. 10.1002/jbmr.5650060815
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- Article
Genetic Influences on Bone Density: Physiological Correlates of Vitamin D Receptor Gene Alleles in Premenopausal Women. Notification of Genotype Corrections.
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- Journal of Clinical Endocrinology & Metabolism, 1998, v. 83, n. 3, p. 1043, doi. 10.1210/jcem.83.3.4668-5
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- Article
Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP‐1 and RANTESCarly L. Magno and Michael S. Kim have contributed equally to the work in this study.
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- Journal of Cellular Biochemistry, 2006, v. 97, n. 3, p. 512, doi. 10.1002/jcb.20649
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- Article
Optimized transfection of diced siRNA into mature primary human osteoclasts: Inhibition of cathepsin K mediated bone resorption by siRNA.
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- Journal of Cellular Biochemistry, 2005, v. 96, n. 5, p. 996, doi. 10.1002/jcb.20575
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- Article
NFAT expression in human osteoclasts.
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- Journal of Cellular Biochemistry, 2005, v. 95, n. 1, p. 17, doi. 10.1002/jcb.20410
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- Article
Gene array identification of osteoclast genes: Differential inhibition of osteoclastogenesis by cyclosporin A and granulocyte macrophage colony stimulating factor.
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- Journal of Cellular Biochemistry, 2004, v. 91, n. 2, p. 303, doi. 10.1002/jcb.10780
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- Article
1α,25-Dihydroxyvitamin D.
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- Journal of Cellular Biochemistry, 1997, v. 67, n. 3, p. 287, doi. 10.1002/(SICI)1097-4644(19971201)67:3<287::AID-JCB1>3.0.CO;2-S
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- Article
Identification of an osteocalcin gene promoter sequence that binds AP1.
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- Journal of Cellular Biochemistry, 1996, v. 60, n. 4, p. 447, doi. 10.1002/(SICI)1097-4644(19960315)60:4<447::AID-JCB2>3.0.CO;2-S
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- Article
Identification of a vitamin D.
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- Journal of Cellular Biochemistry, 1996, v. 60, n. 3, p. 322, doi. 10.1002/(SICI)1097-4644(19960301)60:3<322::AID-JCB4>3.0.CO;2-Y
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- Article
rHox: A homeobox gene expressed in osteoblastic cells.
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- Journal of Cellular Biochemistry, 1995, v. 59, n. 4, p. 486, doi. 10.1002/jcb.240590409
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- Article
G/C element contributes to the cell line-specific expression of the proximal osteocalcin promoter.
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- Journal of Cellular Biochemistry, 1995, v. 58, n. 4, p. 499, doi. 10.1002/jcb.240580413
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- Article
Single injection of PTH improves osteoclastic parameters of remodeling at a stress fracture site in rats.
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- Journal of Orthopaedic Research, 2019, v. 37, n. 5, p. 1172, doi. 10.1002/jor.24262
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- Article
Vitamin D receptor polymorphisms and bone mineral density in Mexican women without osteoporosis.
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- American Journal of Human Biology, 1999, v. 11, n. 6, p. 793, doi. 10.1002/(SICI)1520-6300(199911/12)11:6<793::AID-AJHB10>3.0.CO;2-V
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- Article
CCL2 and CCR2 are Essential for the Formation of Osteoclasts and Foreign Body Giant Cells.
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- Journal of Cellular Biochemistry, 2016, v. 117, n. 2, p. 382, doi. 10.1002/jcb.25282
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- Article
MCP-1 as a Potential Target to Inhibit the Bone Invasion by Oral Squamous Cell Carcinoma.
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- Journal of Cellular Biochemistry, 2014, v. 115, n. 10, p. 1787, doi. 10.1002/jcb.24849
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- Article
Novel Target Genes of RUNX2 Transcription Factor and 1,25-Dihydroxyvitamin D3.
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- Journal of Cellular Biochemistry, 2014, v. 115, n. 9, p. 1594, doi. 10.1002/jcb.24823
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- Article
Differential Expression of Chemokines, Chemokine Receptors and Proteinases by Foreign Body Giant Cells (FBGCs) and Osteoclasts.
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- Journal of Cellular Biochemistry, 2014, v. 115, n. 7, p. 1290, doi. 10.1002/jcb.24781
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- Article
Dominant Negative MCP-1 Blocks Human Osteoclast Differentiation.
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- Journal of Cellular Biochemistry, 2014, v. 115, n. 2, p. 303, doi. 10.1002/jcb.24663
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- Article
Foreign body giant cells and osteoclasts are TRAP positive, have podosome-belts and both require OC-STAMP for cell fusion.
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- Journal of Cellular Biochemistry, 2013, v. 114, n. 8, p. 1772, doi. 10.1002/jcb.24518
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- Article
Differential gene expression in breast cancer cell lines and stroma-tumor differences in microdissected breast cancer biopsies revealed by display array analysis.
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- International Journal of Cancer, 2002, v. 100, n. 2, p. 172, doi. 10.1002/ijc.10451
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- Article
Association of a vitamin D receptor polymorphism with sporadic breast cancer development.
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- International Journal of Cancer, 1999, v. 83, n. 6, p. 723, doi. 10.1002/(SICI)1097-0215(19991210)83:6<723::AID-IJC4>3.0.CO;2-3
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- Article
The B3-Adrenergic Receptor Gene Trp64Arg Mutation Is Overrepresented in Obese Women.
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- Diabetes, 1996, v. 45, n. 10, p. 1358, doi. 10.2337/diab.45.10.1358
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- Article
The Osteocalcin and Collagen Type I (α1) Promoters Share Common Basal Regulatory Units.
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- DNA & Cell Biology, 1995, v. 14, n. 6, p. 519, doi. 10.1089/dna.1995.14.519
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- Article
Commentary: Vitamin D receptor polymorphism and bone mineral density: effect size in Caucasians means detection is uncertain in small studies.
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- International Journal of Epidemiology, 2004, v. 33, n. 5, p. 989, doi. 10.1093/ije/dyh367
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- Article
Intermittent Parathyroid Hormone Accelerates Stress Fracture Healing More Effectively Following Cessation of Bisphosphonate Treatment.
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- JBMR Plus, 2020, v. 4, n. 9, p. 1, doi. 10.1002/jbm4.10387
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- Article