We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Retrospective study on bevacizumab in the treatment of non-small cell lung cancer with brain metastases.
- Authors
Wang, Zhen; Yang, Jin-Ji; Tu, Hai-Yan; Yan, Hong-Hong; Wu, Yi-Long
- Abstract
Background: Bevacizumab was demonstrated to have efficacy in patients with non-small cell lung cancer (NSCLC) and brain metastases. However, cerebral toxicities were a major concern. This study aims to investigate the efficacy and risk factors of toxicity of bevacizumab in brain metastases. Methods: All patients with advanced NSCLC hospitalized in our institute were screened and only those, who underwent bevacizumab administration after the diagnosis of brain metastases, were included. Results: Fifty-one patients, who were treatment naïve or pretreated prior to bevacizumab regimens, were enrolled. Regardless of treatment lines, the objective response rate (ORR) was 62.7% (32/51), progression free survival (PFS) and overall survival were 6.2 months (95%CI, 5.0–7.4) and 14.0 months (95%CI, 9.6–18.4), respectively, and intracranial PFS was 7.8 months (95%CI, 7.1–8.5). For 41 patients with measurable brain metastatic lesions, the intracranial ORR was 46.3% (19/41). Ten patients (19.6%, 10/51) experienced cerebral toxicities (seven cases of grade 1 and three cases of grade 3), including cerebral or intratumoral hemorrhage and ischemic stroke. Cardiovascular disease was the risk factor contributing to cerebral toxicities (OR 16.645; 95%CI, 2.443–113.430; P = 0.004). Conclusions: This retrospective study shows that bevacizumab has efficacy and favorable toxicity in patients with NSCLC and brain metastases and cardiovascular disease might be a risk factor for cerebral toxicity.
- Subjects
NON-small-cell lung carcinoma; BRAIN metastasis; BRAIN tumors; METASTASIS; CARDIOVASCULAR diseases risk factors
- Publication
International Journal of Clinical Oncology, 2020, Vol 25, Issue 2, p267
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-019-01552-5