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- Title
Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting: results of a prospective study.
- Authors
Andresen-Streichert, Hilke; Müller, Alexander; Beres, Yannick; Lohse, Ansgar; Nashan, Björn; Weinmann, Wolfgang; Schröck, Alexandra; Skopp, Gisela; Pischke, Sven; Sterneck, Martina; Vettorazzi, Eik
- Abstract
Phosphatidylethanol ( PEth) is a new, highly specific alcohol marker. The aim of this study was to assess its diagnostic value in the liver transplant setting. In 51 pre- and 61 post-transplant patients with underlying alcoholic liver disease PEth, ethanol, methanol, carbohydrate-deficient transferrin ( CDT), and ethyl glucuronide in urine ( uEtG) and hair ( hEtG) were tested and compared with patients' questionnaire reports. Twenty-eight (25%) patients tested positive for at least one alcohol marker. PEth alone revealed alcohol consumption in 18% of patients. With respect to detection of alcohol intake in the preceding week, PEth showed a 100% sensitivity. PEth testing was more sensitive than the determination of ethanol, methanol, CDT or uEtG alone [sensitivity 25% (confidence interval ( CI) 95%, 7-52%), 25% (7-52%), 21% (6-45%) and 71% (41-91%), respectively], or ethanol, methanol and uEtG taken in combination with 73% (45-92%). Specificity of all markers was 92% or higher. Additional testing of hEtG revealed alcohol consumption in seven patients, not being positive for any other marker. Phosphatidylethanol was a highly specific and sensitive marker for detection of recent alcohol consumption in pre- and post-transplant patients. The additional determination of hEtG was useful in disclosing alcohol consumption 3-6 months retrospectively.
- Subjects
PHOSPHATIDIC acids; LIVER transplantation; ALCOHOLIC liver diseases; ETHANOL; ALCOHOL drinking
- Publication
Transplant International, 2017, Vol 30, Issue 6, p611
- ISSN
0934-0874
- Publication type
Article
- DOI
10.1111/tri.12949