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- Title
Atypical adenomatous hyperplasia of the lung: correlation between high-resolution CT findings and histopathologic features.
- Authors
Kawakami, S.; Sone, S.; Takashima, S.; Li, F.; Yang, Z.-G.; Maruyama, Y.; Honda, T.; Hasegawa, M.; Wang, J.-C.
- Abstract
We describe herein the CT features of atypical adenomatous hyperplasia (AAH) of the lung and its histopathological characteristics. Among 17,919 individuals screened for lung cancer by CT scanning, ten AAH nodules were detected in nine asymptomatic subjects. On high-resolution CT, the lesions measured from 6 x 6 mm to 15 x 17 mm and their CT number ranged from -500 to -760 HU. The AAHs appeared as round nodules with smooth and distinct borders and showed a ground-glass opacity. Plain chest radiographs failed to identify all lesions. Histopathologically, AAH lesions showed atypical epithelial cell proliferation along slightly thickened alveolar septa. Whereas it is often easy to differentiate these nodules from inflammatory and benign lung lesions, histopathological examination remains at present the only method to differentiate AAH from lung cancers.
- Subjects
HYPERPLASIA; CELLULAR pathology; GINGIVAL hyperplasia; BENIGN prostatic hyperplasia; HISTOPATHOLOGY; CELL proliferation
- Publication
European Radiology, 2001, Vol 11, Issue 5, p811
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s003300000790