We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Postoperative [<sup>68</sup>Ga]Ga-DOTA-TATE PET/CT imaging is prognostic for progression-free survival in meningioma WHO grade 1.
- Authors
Teske, Nico; Biczok, Annamaria; Quach, Stefanie; Dekorsy, Franziska J.; Forbrig, Robert; Bodensohn, Raphael; Niyazi, Maximilian; Tonn, Joerg-Christian; Albert, Nathalie L.; Schichor, Christian; Ueberschaer, Moritz
- Abstract
Purpose: Tumor resection represents the first-line treatment for symptomatic meningiomas, and the extent of resection has been shown to be of prognostic importance. Assessment of tumor remnants with somatostatin receptor PET proves to be superior to intraoperative estimation with Simpson grading or MRI. In this preliminary study, we evaluate the prognostic relevance of postoperative PET for progression-free survival in meningiomas. Methods: We conducted a post hoc analysis on a prospective patient cohort with resected meningioma WHO grade 1. Patients received postoperative MRI and [68Ga]Ga-DOTA-TATE PET/CT and were followed regularly with MRI surveillance scans for detection of tumor recurrence/progression. Results: We included 46 patients with 49 tumors. The mean age at diagnosis was 57.8 ± 1.7 years with a male-to-female ratio of 1:1.7. Local tumor progression occurred in 7/49 patients (14%) after a median follow-up of 52 months. Positive PET was associated with an increased risk for progression (*p = 0.015) and a lower progression-free survival (*p = 0.029), whereas MRI was not. 20 out of 20 patients (100%) with negative PET findings remained recurrence-free. The location of recurrence/progression on MRI was adjacent to regions where postoperative PET indicated tumor remnants in all cases. Gross tumor volumes were higher on PET compared to MRI (*p = 0.032). Conclusion: Our data show that [68Ga]Ga-DOTA-TATE PET/CT is highly sensitive in revealing tumor remnants in patients with meningioma WHO grade 1. Negative PET findings were associated with a higher progression-free survival, thus improving surveillance. In patients with tumor remnants, additional PET can optimize adjuvant radiotherapy target planning of surgically resected meningiomas.
- Subjects
PROGRESSION-free survival; COMPUTED tomography; SOMATOSTATIN receptors; MENINGIOMA; TUMOR surgery
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2023, Vol 51, Issue 1, p206
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-023-06400-3