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- Title
Down-regulation of porin M35 in Moraxella catarrhalis by aminopenicillins and environmental factors and its potential contribution to the mechanism of resistance to aminopenicillins.
- Authors
Jetter, Marion; Spaniol, Violeta; Troller, Rolf; Aebi, Christoph
- Abstract
Objectives: The outer membrane protein M35 of Moraxella catarrhalis is an antigenically conserved porin. Knocking out M35 significantly increases the MICs of aminopenicillins. The aim of this study was to determine the biological mechanism of this potentially new antimicrobial resistance mechanism of M. catarrhalis and the behaviour of M35 in general stress situations.
- Subjects
ACUTE otitis media; AMOXICILLIN; PATHOGENIC microorganisms; OBSTRUCTIVE lung diseases; JUVENILE diseases; BETA lactamases; THERAPEUTICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2010, Vol 65, Issue 10, p2089
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkq312