We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Differential regulation of L1 and L2 beta-lactamase expression in Stenotrophomonas maltophilia.
- Authors
Avison, Matthew B; Higgins, Catherine S; Ford, Peter J; von Heldreich, Charlotte J; Walsh, Timothy R; Bennett, Peter M
- Abstract
It has been reported that Stenotrophomonas maltophilia L1 and L2 beta-lactamase expression is coordinated. We have isolated S. maltophilia mutants where (i) L1 is constitutively hyper-expressed and L2 is inducible; (ii) L2 is hyper-expressed and L1 is inducible; and (iii) L1 and L2 are constitutively hyper-expressed. The frequency of isolating type 1 and 2 mutants is c. 10(-7), indicating that promoter mutations are probably not involved and providing strong evidence that L1 and L2 expression is not, after all, coordinated. The frequency of isolating type 3 mutants is c. 10(-9), however, implying that there is a significant overlap between the regulatory mechanisms.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2002, Vol 49, Issue 2, p387
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/49.2.387