We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Chitosan Sponges for Efficient Accumulation and Controlled Release of C-Phycocyanin.
- Authors
Sergeeva, Yana E.; Zakharevich, Anastasia A.; Sukhinov, Daniil V.; Koshkalda, Alexandra I.; Kryukova, Mariya V.; Malakhov, Sergey N.; Antipova, Christina G.; Klein, Olga I.; Gotovtsev, Pavel M.; Grigoriev, Timofei E.
- Abstract
The paper proposed a new porous material for wound healing based on chitosan and C-phycocyanin (C-PC). In this work, C-PC was extracted from the cyanobacteria Arthrospira platensis biomass and purified through ammonium sulfate precipitation. The obtained C-PC with a purity index (PI) of 3.36 ± 0.24 was loaded into a chitosan sponge from aqueous solutions of various concentrations (250, 500, and 1000 mg/L). According to the FTIR study, chitosan did not form new bonds with C-PC, but acted as a carrier. The encapsulation efficiency value exceeded 90%, and the maximum loading capacity was 172.67 ± 0.47 mg/g. The release of C-PC from the polymer matrix into the saline medium was estimated, and it was found 50% of C-PC was released in the first hour and the maximum concentration was reached in 5–7 h after the sponge immersion. The PI of the released C-PC was 3.79 and 4.43 depending on the concentration of the initial solution.
- Subjects
CHITOSAN; POROUS materials; AMMONIUM sulfate; WOUND healing; AQUEOUS solutions; SYNECHOCOCCUS
- Publication
BioTech, 2023, Vol 12, Issue 3, p55
- ISSN
2673-6284
- Publication type
Article
- DOI
10.3390/biotech12030055