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- Title
Hybrid Lipid Nanoformulations for Hepatoma Therapy: Sorafenib Loaded Nanoliposomes—A Preliminary Study.
- Authors
Bartos, Adrian; Iancu, Ioana; Ciobanu, Lidia; Onaciu, Anca; Moldovan, Cristian; Moldovan, Alin; Moldovan, Radu Cristian; Tigu, Adrian Bogdan; Stiufiuc, Gabriela Fabiola; Toma, Valentin; Iancu, Cornel; Al Hajjar, Nadim; Stiufiuc, Rares Ionut
- Abstract
Sorafenib is a multikinase inhibitor that has received increasing attention due to its high efficacy in hepatocellular carcinoma treatment. However, its poor pharmacokinetic properties (limited water solubility, rapid elimination, and metabolism) still represent major bottlenecks that need to be overcome in order to improve Sorafenib's clinical application. In this paper, we propose a nanotechnology-based hybrid formulation that has the potential to overcome these challenges: sorafenib-loaded nanoliposomes. Sorafenib molecules have been incorporated into the hydrophobic lipidic bilayer during the synthesis process of nanoliposomes using an original procedure developed in our laboratory and, to the best of our knowledge, this is the first paper reporting this type of analysis. The liposomal hybrid formulations have been characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), and nanoparticle tracking analysis (NTA) that provided useful information concerning their shape, size, zeta-potential, and concentration. The therapeutic efficacy of the nanohybrids has been evaluated on a normal cell line (LX2) and two hepatocarcinoma cell lines, SK-HEP-1 and HepG2, respectively.
- Subjects
SORAFENIB; HEPATOCELLULAR carcinoma; TRANSMISSION electron microscopy; LIPIDS; LIGHT scattering; CELL lines
- Publication
Nanomaterials (2079-4991), 2022, Vol 12, Issue 16, p2833
- ISSN
2079-4991
- Publication type
Article
- DOI
10.3390/nano12162833