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- Title
Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia Shand et al. Maternal vitamin D status and pregnancy outcomes.
- Authors
Shand, A. W.; Nassar, N.; Von Dadelszen, P.; Innis, S. M.; Green, T. J.
- Abstract
Please cite this paper as: Shand A, Nassar N, Von Dadelszen P, Innis S, Green T. Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia. BJOG 2010;117:1593-1598. To determine in a group of pregnant women if vitamin D status, based on serum 25-hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre-eclampsia or adverse pregnancy outcomes. Prospective cohort study. Vancouver, British Columbia, Canada (49°N). Women attending a specialist antenatal clinic because of clinical or biochemical risk factors for pre-eclampsia ( n = 221). Serum 25OHD concentration measured between 10 and 20 weeks of gestation. Pre-eclampsia and composite adverse pregnancy outcomes. Of the women, 78% were vitamin D insufficient (25OHD <75 nmol/l) and 53% were vitamin D deficient (25OHD <50 nmol/l). There was no difference in the rates of pre-eclampsia, gestational hypertension, preterm birth or composite adverse pregnancy outcomes by 25OHD concentration. Vitamin D deficiency and insufficiency were common in a group of women at high risk of pre-eclampsia; however, it was not associated with subsequent risk of an adverse pregnancy outcome.
- Subjects
VITAMIN D; PREGNANCY; PREECLAMPSIA; SERUM; PREGNANT women; COHORT analysis
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2010, Vol 117, Issue 13, p1593
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/j.1471-0528.2010.02742.x