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- Title
Geriatric Assessment-Identified Deficits in Older Cancer Patients With Normal Performance Status.
- Authors
Jolly, Trevor A.; Deal, Allison M.; Nyrop, Kirsten A.; Williams, Grant R.; Pergolotti, Mackenzi; Wood, William A.; Alston, Shani M.; Gordon, Brittaney‐Belle E.; Dixon, Samara A.; Moore, Susan G.; Taylor, W. Chris; Messino, Michael; Muss, Hyman B.
- Abstract
Background. We investigated whether a brief geriatric assessment (GA) would identify important patient deficits that could affect treatment tolerance and care outcomes within a sample of older cancer patients rated as functionally normal (80%-100%) on the Karnofsky performance status (KPS) scale. Methods. Cancer patients aged ≥65 years were assessed using a brief GA that included both professionally and patient-scored KPS and measures of comorbidity, polypharmacy, cognition, function, nutrition, and psychosocial status. Data were analyzed using descriptive statistics and multivariable logistic regression. Results. The sample included 984 patients: mean age was 73 years (range: 65-99 years), 74% were female, and 89% were white. GA was conducted before (23%), during (41%), or after (36%) treatment. Overall, 54% had a breast cancer diagnosis (n = 528), and 46% (n = 456) had cancers at other sites. Moreover, 81% of participants (n = 796) had both professionally and self-rated KPS ≥80, defined as functionally normal, and those patients are the focus of analysis. In this subsample, 550 (69%) had at least 1 GA-identified deficit, 222 (28%) had 1 deficit, 140 (18%) had 2 deficits, and 188 (24%) had ≥ 3 deficits. Specifically, 43% reported taking ≥9 medications daily, 28% had decreased social activity, 25% had ≥ 4 comorbidities, 23% had ≥ 1 impairment in instrumental activities of daily living, 18% had a Timed Up and Go time ≥ 14 seconds, 18% had ≥ 5% unintentional weight loss, and 12% had a Mental Health Index score ≤76. Conclusion. Within this sample of older cancer patients who were rated as functionally normal by KPS, GA identified important deficits that could affect treatment tolerance and outcomes.
- Subjects
NORTH Carolina; TUMOR treatment; GERIATRIC assessment; CANCER patients; CONFIDENCE intervals; RESEARCH funding; MULTIPLE regression analysis; TREATMENT effectiveness; DATA analysis software; DESCRIPTIVE statistics; KARNOFSKY Performance Status; ODDS ratio
- Publication
Oncologist, 2015, Vol 20, Issue 4, p379
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1634/theoncologist.2014-0247