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- Title
前列腺癌组织中 ERG 蛋白的表达变化及意义.
- Authors
景志亮; 陈永华; 曹军; 赵颖海; 柳建军
- Abstract
Objective To investigate the expression changes and significance of ERG protein in the prostate cancer (PCa) tissues. Methods The prostate tissues from 144 patients with PCa and 100 patients with benign prostatic hyperplasia (BPH) were selected. The expression of ERG protein was detected by immunohistochemical Max Vision method, and their relationships with clinicopathological parameters were analyzed. Results The positive expression rates of ERG protein in the PCa and BPH tissues were 25.0% and 0, respectively (P<0.01). The ERG protein expression in the PCa tissues was not related with age of patient, preoperative PSA value and distant metastasis (all P<0.05), and was negatively correlated with Gleason score (r =- 0.175, P<0.05). The ERG protein expression rate in the Gleason score≤7 group was significantly higher than that of the Gleason score 7 group (P<0.05). Conclusion The expression of ERG protein in the prostate cancer tissues of PCa patients is increased, and the ERG protein detection may provide a reference for the differential diagnosis and pathological grading.
- Publication
Shandong Medical Journal, 2016, Vol 56, Issue 1, p12
- ISSN
1002-266X
- Publication type
Article
- DOI
10.3969/j.issn.1002-266X.2016.01.004