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- Title
DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease.
- Authors
Torres, Viviana; Pérez‐Montesino, Jesica; Fernández‐Santiago, Rubén; Fernández, Manel; Camara, Ana; Compta, Yaroslau; Martí, María‐José; Guerra Beltran, Àlex; Rios, José; Valldeoriola, Francesc; Ezquerra, Mario
- Abstract
Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors. In this retrospective study, we analyzed a cohort of Parkinson's disease patients treated with dopamine agonists and investigated the influence of the dopamine D4 receptor gene polymorphism, DRD4 7R+, which is linked to psychiatric disorders, impulsive traits, and addictive behaviors. We found that DRD4 7R+ is a significant genetic risk factor associated with the severity of ICD.
- Subjects
PARKINSON'S disease; DOPAMINE receptors; GENETIC polymorphisms; COMPULSIVE behavior; DOPAMINE agonists; IMPULSE control disorders
- Publication
Annals of Clinical & Translational Neurology, 2024, Vol 11, Issue 8, p2222
- ISSN
2328-9503
- Publication type
Article
- DOI
10.1002/acn3.52111