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- Title
Action and Interaction of Amyloid-β and Insulin on Dopamine Release and Reuptake in the Dorsal Lateral Striatum of Rats.
- Authors
Mukhin, V. N.; Borovets, I. R.; Sizov, V. V.; Klimenko, V. M.
- Abstract
Accumulation of amyloid-β (Aβ) in the brain is an important link in the pathogenesis of Alzheimer's disease. Experimental studies show that Aβ can cause dopaminergic dysfunction that is characteristic of this disease and, under Aβ influence, not only the decrease but also the increase in phasic dopamine release is possible, depending on the structure of the brain. We aimed to investigate whether Aβ in a toxic form affects dopamine release or reuptake in the dorsal lateral striatum and, if so, whether this influence is mediated by the insulin signaling pathway. Aβ (fragment 25–35) and insulin solutions were injected into the ventricular system of the anesthetized male Wistar rats. Within 10 min before and 30 min after the injection, electrically evoked dopamine elevations were registered with fast-scan cyclic voltammetry every 5 min. Release and reuptake were assessed separately by kinetic analysis. The results show that Aβ acts on dopamine release and reuptake in the dorsal lateral striatum in several ways. It modulates the effect of insulin on dopamine release and reuptake. In addition, Aβ increases dopamine release and basal levels by acting separately from the insulin signaling pathway.
- Subjects
DOPAMINE; INSULIN; DOPAMINE receptors; ALZHEIMER'S disease; CYCLIC voltammetry; RATS; LABORATORY rats; BRAIN anatomy
- Publication
Journal of Evolutionary Biochemistry & Physiology, 2024, Vol 60, Issue 1, p162
- ISSN
0022-0930
- Publication type
Article
- DOI
10.1134/S0022093024010125