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- Title
Özofagus Atrezisi Operasyonu Sonrası Gelişen Dirençli Atelektazinin rhDNase ile Tedavisi.
- Authors
YILMAZ, Engin; AFŞARLAR, Çağatay Evrim; ERTÜRK, Ahmet; KARAMAN, Ayşe; KARAMAN, İbrahim; OKUMUŞ, Nurullah; ŞENEL, Emrah
- Abstract
There is no previous literature report on the use of rhDNase treatment in patients developing resistant atelectasis after esophagus atresia surgery, to the best of our knowledge. We aimed to present the results of rhDNase treatment in two cases that developed right lung atelectasis after esophageal atresia repair and did not respond to conventional treatment. A 15-day-old girl was operated for esophageal atresia with distal tracheoesophageal fistula and developed right lung atelectasis on the postoperative 11 th day. Standard conservative treatment failed and rigid bronchoscopy was performed on the postoperative 20th day. The atelectasis partly improved but subsequently recurred. We started nebulization with rhDNase on postoperative day 26 and three doses per day were administered for 2 days with each dose containing 1.25 mg of rhDNase. A chest X-ray was obtained at the end of the three doses. A full recovery in the patient's atelectasis was observed after 2 days and no recurrence occurred. A 7-day-old boy who underwent esophageal atresia with distal tracheoesophageal fistula repair when 3 days old developed right atelectasis. The patient received standard treatment but the atelectasis did not improve. The patient was treated with rhDNase for two days starting on the 9th postoperative day using the same dose as the first case. A full recovery in the patient's atelectasis was observed after 2 days and no recurrence occurred. We found rhDNase treatment to be potentially useful to cope with resistant atelectasis of postoperative origin in newborns that have undergone surgical intervention for esophagus atresia.
- Subjects
ATELECTASIS; ESOPHAGEAL atresia; DEOXYRIBONUCLEASES; THERAPEUTICS
- Publication
Journal of Pediatric Disease / Türkiye Çocuk Hastalıkları Dergisi, 2016, Vol 10, Issue 3, p219
- ISSN
1307-4490
- Publication type
Article
- DOI
10.12956/tjpd.2015.178