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- Title
Concomitant neoplasms in the skin and stomach unveil the role of type IV collagen and E-cadherin in mucin core protein 5 AC expression in vivo.
- Authors
Hata, H.; Natsuga, K.; Kitamura, S.; Imafuku, K.; Yamaguchi, Y.; Ebihara, Y.; Shichinohe, T.; Hirano, S.; Shimizu, H.
- Abstract
Mucin core protein ( MUC) 5 AC is a gel-forming glycoprotein that is expressed in different types of tumour cells. MUC5 AC expression in cultured cells is regulated through the extracellular matrix and through remodelling by other membranous proteins such as type IV collagen ( COL4) and E-cadherin. However, it has not been elucidated whether COL4 and E-cadherin affect MUC5 AC expression in tumours in vivo. Here, by analysing a single individual with concomitant neoplasms in the skin [extramammary Paget disease ( EMPD)] and the stomach (gastric cancer), we show that MUC5 AC expression is reduced in COL4 and membranous E-cadherin-expressing EMPD specimens whereas MUC5 AC is not abolished in gastric cancer with COL4 negativity and E-cadherin cytoplasmic localization. As the EMPD and gastric cancer specimens were derived from a single patient, each specimen had the same genetic background. These in vivo results support previous in vitro studies which showed that COL4 and E-cadherin downregulated MUC5 AC expression. Our study suggests that concomitant neoplasms in different organs of the same individual can serve as a strong tool for uncovering functional diversity in tumour markers in distinct cancer cells.
- Subjects
TUMOR diagnosis; GENE expression; PATIENT management; CANCER cell analysis; GLYCOPROTEIN analysis
- Publication
British Journal of Dermatology, 2016, Vol 174, Issue 2, p395
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/bjd.14084