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- Title
Paradoxical Roles of the neutrophil in Sepsis: Protective and Deleterious.
- Authors
Sônego, Fabiane; E Silva Castanheira, Fernanda Vargas; Ferreira, Raphael Gomes; Kanashiro, Alexandre; Gonçalves Leite, Caio Abner Vitorino; Nascimento, Daniele Carvalho; Colón, David Fernando; De Fátima Borges, Vanessa; Alves-Filho, José Carlos; Cunha, Fernando Queiróz; Souza, Daniele; Cassatella, Marco A.
- Abstract
Sepsis, an overwhelming inflammatory response syndrome secondary to infection, is one of the costliest and deadliest medical conditions worldwide. Neutrophils are classically considered to be essential players in the host defense against invading pathogens. However, several investigations have shown that impairment of neutrophil migration to the site of infection, also referred to as neutrophil paralysis, occurs during severe sepsis, resulting in an inability of the host to contain and eliminate the infection. On the other hand, the neutrophil antibacterial arsenal contributes to tissue damage and the development of organ dysfunction during sepsis. In this review, we provide an overview of the main events in which neutrophils play a beneficial or deleterious role in the outcome of sepsis.
- Subjects
SEPTICEMIA treatment; NEUTROPHILS; PATHOGENIC microorganisms; THERAPEUTICS
- Publication
Frontiers in Immunology, 2016, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2016.00155