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- Title
The role of fatty acid oxidation in the metabolic reprograming of activated T-cells.
- Authors
Byersdorfer, Craig Alan; Mauro, Claudio; Lochner, Matthias
- Abstract
Activation represents a significant bioenergetic challenge for T-cells, which must undergo metabolic reprogramming to keep pace with increased energetic demands. This review focuses on the role of fatty acid metabolism, both in vitro and in vivo, following T-cell activation. Based upon previous studies in the literature, as well as accumulating evidence in allogeneic cells, I propose a multi-step model of in vivo metabolic reprogramming. In this model, a primary determinant of metabolic phenotype is the ubiquity and duration of antigen exposure. The implications of this model, as well as the future challenges and opportunities in studying T-cell metabolism, will be discussed.
- Subjects
FATTY acid oxidation; BIOENERGETICS; T cells; CELL metabolism; ANTIGENS
- Publication
Frontiers in Immunology, 2014, Vol 5, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2014.00641