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- Title
Systematic review: patient-centred endpoints in economic evaluations of gastro-oesophageal reflux disease.
- Authors
Vakil, N.; Rydén‐Bergsten, T.; Bergenheim, K.
- Abstract
Summary Aim : To perform a systematic review of the economic literature on gastro-oesophageal reflux disease to evaluate (a) the use of patient-centred effectiveness end-points, or (b) the use of patient-centred economic end-points, and the influence of these end-points on the outcome of the model. Methods : Three electronic databases (EMBASE, BIOSIS and Medline) were used, together with a manual search of meeting abstracts for relevant articles. The quality of the studies was determined by the Drummond criteria. Results : Our initial search identified 179 articles and a manual search revealed 78 abstracts and articles. A total of 47 studies (36 fully published articles and 11 abstracts) met the seven Drummond criteria for inclusion in our evaluation. Conclusions : This systematic review demonstrates that many of the published economic evaluations available today take the perspective of the third-party payer and focus on pharmaceutical costs relevant to the third-party payer. Our study also demonstrates that there are a number of costs of illness determinations, such that pharmaceutical costs account for only a small proportion of the total costs of managing gastro-oesophageal reflux disease. Future economic analyses should consider an evaluation of the patient's desire for complete symptom relief by including cost–utility assessments or willingness to pay data.
- Subjects
GASTROESOPHAGEAL reflux; MEDICAL care costs
- Publication
Alimentary Pharmacology & Therapeutics, 2002, Vol 16, Issue 8, p1469
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1046/j.1365-2036.2002.01303.x