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- Title
A Case of Hepatic Glomerulosclerosis with Monoclonal IgA1-κ Deposits.
- Authors
Okabayashi, Yusuke; Tsuboi, Nobuo; Nakaosa, Naoko; Haruhara, Kotaro; Kanzaki, Go; Koike, Kentaro; Shimizu, Akihiro; Fukui, Akira; Okonogi, Hideo; Miyazaki, Yoichi; Kawamura, Tetsuya; Ogura, Makoto; Shimizu, Akira; Yokoo, Takashi
- Abstract
Glomerular immunoglobulin A (IgA) deposition is a common finding in hepatic glomerulosclerosis; thus, this disease is also called hepatic IgA nephropathy. However, only a small number of patients with hepatic IgA nephropathy have active glomerular lesions, so functional decline is slow in most cases. In this report, we describe a 60-year-old man who developed nephrotic syndrome and progressive renal impairment during follow-up for alcoholic liver cirrhosis. A renal biopsy showed a membranoproliferative glomerulonephritis-like pattern; diffuse double-contours of the glomerular basement membrane and focal active glomerular lesions with moderate-to-severe endocapillary proliferation and fibrocellular crescents. Immunofluorescence findings revealed granular staining for monoclonal IgA1-κ and C3 on the peripheral capillary walls. Laboratory examinations did not reveal any definitive evidence of myeloproliferative disorders. Therefore, this case may represent a previously unrecognized etiology of renal injury in relation to liver cirrhosis that is characterized by monoclonal IgA1-κ deposits and proliferative glomerulonephritis.
- Subjects
IGA glomerulonephritis; NEPHROTIC syndrome; GLOMERULAR filtration rate; MONOCLONAL antibodies; FIBROSIS
- Publication
Case Reports in Nephrology, 2018, p1
- ISSN
2090-6641
- Publication type
Case Study
- DOI
10.1155/2018/4748357