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- Title
Umbilical cord blood transplantation and unmanipulated haploidentical hematopoietic SCT for pediatric hematologic malignances.
- Authors
Mo, X-D; Zhao, X-Y; Liu, D-H; Chen, Y-H; Xu, L-P; Zhang, X-H; Chen, H; Han, W; Wang, Y; Wang, F-R; Wang, J-Z; Liu, K-Y; Huang, X-J
- Abstract
This study aimed to compare the therapeutic effects of single umbilical cord blood transplantation (UCBT) and unmanipulated haploidentical hematopoietic SCT (haplo-HSCT) in childhood hematologic malignances. We enrolled 410 consecutive children who received either single UCBT (n=37) or haplo-HSCT from a family donor (n=373) during the same time period. For each UCBT recipient, three recipients matched for year of HSCT, underlying diseases, disease status and the length of follow-up were randomly selected from the haplo-HSCT cohort. Hematopoietic recovery was significantly faster in haplo-HSCT recipients than in UCBT recipients. The incidence of chronic GVHD was significantly higher in haplo-HSCT recipients. The incidence of CMV-related interstitial pneumonia was higher in UCBT recipients. The haplo-HSCT recipients had better 1-year OS (73.0% vs 56.8%, P=0.048), lower 1-year non-relapse mortality (NRM, 18.0% vs 35.1%, P=0.026) and lower 2-year NRM rates (19.9% vs 35.1%, P=0.044). The relapse- and disease-free survival rates did not differ significantly between the groups. Our results showed that compared with UCBT, unmanipulated haplo-HSCT can improve the outcomes of children with hematologic malignances.
- Subjects
CORD blood transplantation; HEMATOPOIETIC stem cell transplantation; MORTALITY risk factors; CANCER chemotherapy; CLINICAL trials
- Publication
Bone Marrow Transplantation, 2014, Vol 49, Issue 8, p1070
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/bmt.2014.109