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- Title
Elevated monocytic myeloid‐derived suppressor cells positively correlate with infection frequency in children with RRTIs.
- Authors
Ji, Jianjian; Ren, Lishun; Liu, Yuling; Zheng, Min; Fang, Huazhong; Xu, Hui; He, Huizhen; Zhang, Min; Wang, Xianzheng; Shan, Jinjun; Hou, Yayi
- Abstract
GLO:BVO/01nov21:eji4936-gra-0001.jpg PHOTO (COLOR): . gl Abbreviations MDSCs myeloid derived suppressor cells RRTIs Recurrent respiratory tract infections URIs Upper respiratory tract infections LRIs Lower respiratory tract infections G-MDSCs granulocytic MDSCs M-MDSCs monocytic MDSCs RTIs respiratory tract infections Recurrent respiratory tract infections (RRTIs) are very common and affect a large proportion of children [1, 2]. Keywords: CD8+ T cell; infection frequency; myeloid-derived suppressor cells; recurrent respiratory tract infections EN CD8+ T cell infection frequency myeloid-derived suppressor cells recurrent respiratory tract infections 2687 2690 4 11/05/21 20211101 NES 211101 In children with recurrent respiratory tract infections (RRTIs), the percentages and numbers of monocytic myeloid-derived suppressor cells (MDSCs) were elevated. MDSCs were isolated from RRTIs and controls children, respectively, and then co-cultured with CD8 SP + sp T cells, and the proliferation of CD8 SP + sp T cells was subsequently assessed. Elevated monocytic myeloid-derived suppressor cells positively correlate with infection frequency in children with RRTIs.
- Subjects
MYELOID-derived suppressor cells; MYELOID cells; RESPIRATORY infections
- Publication
European Journal of Immunology, 2021, Vol 51, Issue 11, p2687
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.202048629