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- Title
β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells.
- Authors
Tian, Jie; Ma, Jie; Ma, Ke; Guo, Hongye; Baidoo, Samuel Essien; Zhang, Yue; Yan, Jun; Lu, Liwei; Xu, Huaxi; Wang, Shengjun
- Abstract
Myeloid-derived suppressor cells ( MDSCs) accumulate in tumor-bearing hosts and play a major role in tumor-induced immunosuppression, which hampers effective immuno-therapeutic approaches. β-Glucans have been reported to function as potent immuno-modulators to stimulate innate and adaptive immune responses, which contributes to their antitumor property. Here, we investigated the effect of particulate β-glucans on MDSCs and found that β-glucan treatment could promote the differentiation of M- MDSCs (monocytic MDSCs) into a more mature CD11c+ F4/80+ Ly6Clow population via dectin-1 pathway in vitro, which is NF-κB dependent, and the suppressive function of M- MDSCs was significantly decreased. Treatment of orally administered yeast-derived particulate β-glucan drastically downregulated MDSCs but increased the infiltrated DCs and macrophages in tumor-bearing mice, thus eliciting CTL and Th1 responses, inhibiting the suppressive activity of regulatory T cells, thereby leading to the delayed tumor progression. We show here for the first time that β-glucans induce the differentiation of MDSCs and inhibit the regulatory function of MDSCs, therefore revealing a novel mechanism for β-glucans in immunotherapy and suggesting their potential clinical benefit.
- Publication
European Journal of Immunology, 2013, Vol 43, Issue 5, p1220
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201242841