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- Title
Combining epigenetic therapy with venetoclax overcomes alemtuzumab resistance in T-cell prolymphocytic leukemia. A case report of a 26-year-old man with a prior history of T-cell acute lymphoblastic leukemia and GI-T lymphoma.
- Authors
Andersen, Michael Asger; Valentin, Rebecca; Dissing Sjö, Lene; Borgwardt, Line; Schmiegelow, Kjeld; Andersen, Mette Klarskov; Marvig, Rasmus L.; Yde, Christina Westmose; Niemann, Carsten Utoft
- Abstract
A case report of a 26-year-old man who is presented with a prior history of T-cell acute lymphoblastic leukemia and GI-T lymphoma, is presented. Topics include cladribine is discussed along with clinical, morphological, immunophenotypic, molecular, genetic, and cytogenetic features; and cytoplasm was basophilic, without granulation while a proportion of the cells showed small membranous protrusions.
- Subjects
THERAPEUTIC use of antineoplastic agents; DRUG resistance in cancer cells; LYMPHOBLASTIC leukemia; LYMPHOMAS; MONOCLONAL antibodies; RARE diseases; T cells; GASTROINTESTINAL tumors; TREATMENT effectiveness; EPIGENOMICS
- Publication
Acta Oncologica, 2020, Vol 59, Issue 12, p1547
- ISSN
0284-186X
- Publication type
Case Study
- DOI
10.1080/0284186X.2020.1821913