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- Title
NIR-II fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis.
- Authors
Lu, Siyu; Xue, Liru; Yang, Meng; Wang, Jingjing; Li, Yang; Jiang, Yuxin; Hong, Xuechuan; Wu, Mingfu; Xiao, Yuling
- Abstract
Ovarian cancer is a global problem, and is typically diagnosed in the middle or late stages, with a mysterious abdominal mass or atypical abdominal metastases due to the lack of specific initial diagnostic methods. Dual-modal near-infrared II (NIR-II, 1,000–1,700 nm) fluorescence/photoacoustic imaging has great potential in early ovarian cancer diagnosis and image-guided surgery due to its high sensitivity and deep penetration. Herein, we report a novel organic NIR-II dye (H10) with excellent aggregation-induced-emission (AIE) characteristics (I/I0 > 1.6) utilizing a selenadiazolo-[3,4-f]benzo[c][1,2,5]thiadiazole (ST)-based building block. Then, water-soluble and biocompatible H10@follicle-stimulating hormone (H10@FSH) dots with superior optical/photoacoustic properties and a tenfold increase in ovarian-specific targeting ability were synthesized. Finally, for the first time, in vivo dual-mode NIR-II fluorescent/photoacoustic (PA) imaging and image-guided surgery of patient-derived tumor xenograft (PDTX) and micro-metastatic abdominal ovarian cancer lesions were investigated. This novel strategy will establish a new method for early detection of ovarian cancer and significantly improve the prognosis of ovarian cancer patients.
- Publication
Nano Research, 2022, Vol 15, Issue 10, p9183
- ISSN
1998-0124
- Publication type
Article
- DOI
10.1007/s12274-022-4592-z