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- Title
Antimicrobial activity of Myagropsis myagroides and interaction with food composition.
- Authors
Lee, So-Young; Song, Eu-Jin; Kim, Koth-Bong-Woo-Ri; Lim, Seong-Il; Hong, Yong-Ki; Ahn, Dong-Hyun
- Abstract
Ethanol extract of Myagropsis myagroides (MMEE) has substantial antimicrobial activity against Gram-positive bacteria and some of the yeasts. The minimum inhibitory concentration (MIC) of MMEE ranged from 0.0625 to 0.125 mg/mL for Bacillus subtilis, Listeria monocytogenes, and Clostridium perfringens. Chloroform fraction obtained through liquid-liquid extraction possessed the strongest antimicrobial activity, and was separated by silica gel column chromatography. Among 22 of subfraction, CH4 showed the strongest activity (4-8 times MIC of the crude extract). The antimicrobial activity of CH4 to Staphylococcus aureus was reduced at high concentrations of starch, but the bactericidal effect of CH4 was maintained at 1 and 5% starch model media. The efficacy of CH4 against S. aureus diminished in the presence of >5% beef extract and >1% soybean oil. In acute toxicity test, no mortalities occurred in mice administered 5 g/kg body weight of MMEE over 2 weeks observation.
- Publication
Food Science & Biotechnology, 2011, Vol 20, Issue 1, p85
- ISSN
1226-7708
- Publication type
Article
- DOI
10.1007/s10068-011-0012-y