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- Title
Meta-Analyses of 8 Polymorphisms Associated with the Risk of the Alzheimer’s Disease.
- Authors
Xu, Xuting; Wang, Yunliang; Wang, Lingyan; Liao, Qi; Chang, Lan; Xu, Leiting; Huang, Yi; Ye, Huadan; Xu, Limin; Chen, Cheng; Shen, Xiaowei; Zhang, Fuqiang; Ye, Meng; Wang, Qinwen; Duan, Shiwei
- Abstract
Aims: The aim of this study was to evaluate the combined contribution of 8 polymorphisms to the risk of Alzheimer's disease (AD). Methods: Through a comprehensive literature search for genetic variants involved in the AD association study, we harvested a total of 6 genes (8 polymorphisms) for the current meta-analyses. These genes consisted of A2M (5bp I/D and V1000I), ABCA2 (rs908832), CHAT (1882G >A, 2384G >A), COMT (Val158Met), HTR6 (267C >T) and LPL (Ser447Ter). Results: A total of 33 studies among 9,453 cases and 10,833 controls were retrieved for the meta-analyses of 8 genetic variants. It was showed that A2M V1000I (odd ratio (OR) = 1.26, 95% confidence interval (CI) = 1.07–1.49, P = 0.007), rs908832 allele of ABCA2 (OR = 1.55, 95% CI = 1.12–2.16, P = 0.009), 2384G >A of CHAT (OR = 1.22, 95% CI = 1.00–1.49, P = 0.05) and Ser447Ter of LPL in the Northern-American population (OR = 0.56, 95% CI = 0.35–0.91, P = 0.02) were significantly associated with the risk of AD. No association was found between the rest of the 5 polymorphisms and the risk of AD. Conclusion: Our results showed that A2M V1000I polymorphism in German, Korean, Chinese, Spanish, Italian and Polish populations, rs90883 of ABCA2 gene in French, American, Swiss, Greek and Japanese populations, 2384G >A of CHAT gene in British and Korean populations and LPL Ser447Ter in the Northern-American population were associated with the risk of AD.
- Subjects
ALZHEIMER'S disease risk factors; GENETICS of Alzheimer's disease; GENETIC polymorphisms; META-analysis; POPULATION dynamics; CONTROL groups; MEDICAL statistics
- Publication
PLoS ONE, 2013, Vol 8, Issue 9, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0073129