We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Role of VEGF and KDR Polymorphisms in Moyamoya Disease and Collateral Revascularization.
- Authors
Young Seok Park; Young Joo Jeon; Hyun Seok Kim; Kyu Young Chae; Seung-Hun Oh; In Bo Han; Hyun Sook Kim; Won-Chan Kim; Ok-Joon Kim; Tae Gon Kim; Joong-Uhn Choi; Dong-Seok Kim; Nam Keun Kim
- Abstract
We conducted a case-control study to investigate whether vascular endothelial growth factor (VEGF -2578, -1154, -634, and 936) and kinase insert domain containing receptor (KDR -604, 1192, and 1719) polymorphisms are associated with moyamoya disease. Korean patients with moyamoya disease (n = 107, mean age, 20.9±15.9 years; 66.4% female) and 243 healthy control subjects (mean age, 23.0±16.1 years; 56.8% female) were included. The subjects were divided into pediatric and adult groups. Among the 64 surgical patients, we evaluated collateral vessel formation after 2 years and divided patients into good (collateral grade A) or poor (collateral grade B and C) groups. The frequencies and distributions of four VEGF (-2578, -1154, -634, and 936) and KDR (-604, 1192, and 1719) polymorphisms were assessed from patients with moyamoya disease and compared to the control group. No differences were observed in VEGF -2578, -1154, -634, and 936 or KDR -604, 1192, and 1719 polymorphisms between the control group and moyamoya disease group. However, we found the -634CC genotype occurred less frequently in the pediatric moyamoya group (p = 0.040) whereas the KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024). Patients with the CC genotype of VEGF -634 had better collateral vessel formation after surgery. Our results suggest that the VEGF 2634G allele is associated with pediatric moyamoya disease and poor collateral vessel formation.
- Subjects
CASE-control method; VASCULAR endothelial growth factors; MOYAMOYA disease; GENETIC polymorphisms; CONTROL groups; SURGERY
- Publication
PLoS ONE, 2012, Vol 7, Issue 10, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0047158