We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung Adenocarcinoma.
- Authors
Gibbons, Don L.; Wei Lin; Creighton, Chad J.; Shuling Zheng; Berel, Dror; Yang, Yanan; Raso, Maria Gabriela; Liu, Diane D.; Wistuba, Ignacio I.; Lozano, Guillermina; Kurie, Jonathan M.
- Abstract
Background: Non-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize. The biologic basis for NSCLC metastasis is not well understood. Methodology/Principal Findings: Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified 2,209 genes that were differentially expressed in distant metastases relative to matched lung tumors. Mining of publicly available data bases revealed this expression signature in a subset of NSCLC patients who had a poorer prognosis than those without the signature. Conclusions/Significance: These findings provide evidence that K-rasG12D; p53R172H mice recapitulate features of human NSCLC metastasis and will provide a useful platform on which to study the biologic basis for lung adenocarcinoma metastasis and its prevention by novel agents.
- Subjects
MICE behavior; ANIMAL models in research; ANIMAL experimentation; ADENOCARCINOMA; SMALL cell lung cancer; CANCER invasiveness; CANCER cell growth
- Publication
PLoS ONE, 2009, Vol 4, Issue 4, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0005401