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- Title
Age-Dependent Fecal Bacterial Correlation to Inflammatory Bowel Disease for Newly Diagnosed Untreated Children.
- Authors
Nwosu, Felix Chinweije; Thorkildsen, Lill-Therse; Avershina, Ekaterina; Ricanek, Petr; Perminow, Gøri; Brackmann, Stephan; Vatn, Morten H.; Rudi, Knut
- Abstract
The knowledge about correlation patterns between the fecal microbiota and inflammatory bowel diseases (IBD)--comprising the two subforms Crohn's disease (CD) and ulcerative colitis (UC)--for newly diagnosed untreated children is limited. To address this knowledge gap, a selection of faecal specimens (CD, n = 27 and UC, n = 16) and non-IBD controls (n = 30) children (age < 18 years) was analysed utilising bacterial small subunit (SSU) rRNA. We found, surprising age dependence for the fecal microbiota correlating to IBD.Themost pronounced patternswere that E. coli was positively (R² = 0.16, P = 0.05) and Bacteroidetes, negatively (²2 = 0.15, P = 0.05) correlated to age for CD patients. For UC, we found an apparent opposite age-related disease correlation for both Bacteroides and Escherichia. In addition, there was an overrepresentation of Haemophilus for the UC children. From our, results we propose a model where the aetiology of IBD is related to an on-going immunological development in children requiring different age-dependent bacterial stimuli. The impact of our findings could be a better age stratification for understanding and treating IBD in children.
- Subjects
INFLAMMATORY bowel disease diagnosis; FECES; MICROBIOLOGY; CROHN'S disease; ULCERATIVE colitis; PEDIATRIC diagnosis; ETIOLOGY of diseases; GASTROENTEROLOGY
- Publication
Gastroenterology Research & Practice, 2013, p1
- ISSN
1687-6121
- Publication type
Article
- DOI
10.1155/2013/302398