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- Title
YKL-40 level in gingival crevicular fluid from patients with periodontitis and type 2 diabetes.
- Authors
Kido, J; Bando, Y; Bando, M; Kajiura, Y; Hiroshima, Y; Inagaki, Y; Murata, H; Ikuta, T; Kido, R; Naruishi, K; Funaki, M; Nagata, T
- Abstract
Objective YKL-40 is a chitin-binding glycoprotein, the level of which increases in inflammatory diseases, diabetes mellitus ( DM), cardiovascular diseases, and tumors. Gingival crevicular fluid ( GCF) contains many proteins and markers of periodontitis. The purpose of this study was to investigate YKL-40 level in GCF from patients with periodontitis and DM and the association between YKL-40 level and chronic periodontitis ( CP) or DM. Subjects and Methods The subjects were 121 patients with DM, CP, DM and periodontitis ( DM-P), and healthy subjects (H). GCF was collected using paper strips after the sites for GCF collection were clinically evaluated for probing depth ( PD), gingival index ( GI), and bleeding on probing ( BOP). YKL-40 in GCF was identified by Western blotting, and its level was determined by ELISA. Results YKL-40 was contained in GCF samples from H, DM, CP, and DM-P sites, and its levels (amount and concentration) in CP and DM-P were significantly higher than those in H and DM. GCF YKL-40 level significantly correlated with PD and GI, and its level in BOP-positive sites was significantly higher than that in BOP-negative ones. Conclusions GCF YKL-40 level was elevated in periodontitis, but not DM. YKL-40 in GCF may be an inflammatory marker for periodontitis.
- Subjects
GINGIVA; GLYCOPROTEIN analysis; ENZYME-linked immunosorbent assay; TYPE 2 diabetes; PERIODONTITIS; RESEARCH funding; STATISTICS; WESTERN immunoblotting; DATA analysis; CASE-control method; DESCRIPTIVE statistics; MANN Whitney U Test; PHYSIOLOGY
- Publication
Oral Diseases, 2015, Vol 21, Issue 5, p667
- ISSN
1354-523X
- Publication type
Article
- DOI
10.1111/odi.12334