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- Title
The Effect of Raloxifene on Markers of Bone Turnover in Older Women Living in Long-Term Care Facilities.
- Authors
Hansdóttir, Helga; Franzsons, Leifur; Prestwood, Karen; Sigur&dacute;sson, Gunnar
- Abstract
To examine the effect of raloxifene on bone turnover in elderly women. Clinical intervention. Long-term care facilities. Nineteen women completed the study, mean age 85 (range 76–99). Raloxifene 60 mg was given daily for 12 weeks. Markers of bone turnover were plasma C-telopeptides of type I collagen (CTx), urine cross-linked N-telopeptides of type I collagen (NTx) and serum tartrate–resistant acid phosphatase (TRAP 5b), plasma osteocalcin, and serum bone alkaline phosphatase. Other markers were serum 25-OH vitamin D, parathyroid hormone, ionized calcium, and phosphate. Markers were measured at baseline, after calcium and vitamin D had been taken for 6 weeks, after raloxifene had been taken for 12 weeks, and 6 weeks after raloxifene had been stopped. Paired sample t test was used to examine changes in markers at each time point. Plasma CTx decreased on average by 31%, urinary NTx by 35%, plasma osteocalcin by 25%, serum bone alkaline phosphatase by 15% ( P<.01), and serum TRAP 5b by 10% ( P<.05) on treatment. Raloxifene reduces bone turnover in elderly women living in long-term care facilities. The effect of raloxifene on bone turnover is comparable with that seen in younger postmenopausal women.
- Subjects
RALOXIFENE; OSTEOPOROSIS; OSTEOPOROSIS in women; OLDER women; LONG-term care facilities; BONES
- Publication
Journal of the American Geriatrics Society, 2004, Vol 52, Issue 5, p779
- ISSN
0002-8614
- Publication type
Article
- DOI
10.1111/j.1532-5415.2004.52218.x